PATENTS AND REGULATORY EXCLUSIVITIES ON FDA-APPROVED INSULIN PRODUCTS: A LONGITUDINAL DATABASE STUDY, 1986-2019.

Patents and regulatory exclusivities on FDA-approved insulin products: A longitudinal database study, 1986-2019.

BackgroundInsulin is the primary treatment for type 1 and some type 2 diabetes but remains costly in the United States, even though it was discovered more than a century ago.High prices can lead to nonadherence and are often sustained by patents and regulatory exclusivities that limit competition on brand-name products.We sought to examine how manu

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Secoiridoids from the Seed of Gonocaryum calleryanum and Their Inhibitory Potential on LPS-Induced Tumor Necrosis Factor and Nitric Oxide Production

Three new secoiridoid constituents, goncarin A−C (1–3), and a new derivative, goncarin A monoacetate (4), along with Acrylic Fridge Magnet two known lignins, pinoresinol (5) and paulownin (6), were isolated from the seed of Gonocaryum calleryanum (Baill.) Becc.The structures of the new metabolites were determined on the basis of extensi

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Investigation of pulping and paper making potential of weeds

Increasing use of wood products accompanying with resource constraint has revealed the importance of nonwood based material.In this study, pulping and papermaking potential of three varieties of weeds including Xanthium spinosum, Carthamus tinctorius and Cyperus papyrus have been considered.At first, chemical components of the samples i.e.cellulose

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